Prevalence and factors associated with latent tuberculosis infection in an indigenous population in the Brazilian Amazon

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dc.contributor.authorMalacarne, Jocieli
dc.contributor.authorRios, Diana Patrícia Giraldo
dc.contributor.authorSilva, Cosme Marcelo Furtado Passos da
dc.contributor.authorBraga, José Ueleres
dc.contributor.authorCamacho, Luiz Antonio Bastos
dc.contributor.authorBasta, Paulo Cesar
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.en_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.en_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.en_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.en_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.en_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Endemias Samuel Pessoa. Rio de Janeiro, RJ, Brasil.en_US
dc.date.accessioned2019-09-16T15:56:28Z
dc.date.available2019-09-16T15:56:28Z
dc.date.issued2016
dc.description.abstractINTRODUCTION Recent studies have shown a high incidence and prevalence of latent tuberculosis infection (LTBI) in indigenous populations around the World. We aimed to estimate the prevalence and annual risk of infection (ARI) as well as to identify factors associated with LTBI in an indigenous population from the Brazilian Amazon. METHODS We conducted a cross-sectional study in 2011. We performed tuberculin skin tests (TSTs), smears and cultures of sputum samples, and chest radiographs for individuals who reported cough for two or more weeks. Associations between LTBI (TST ≥5mm) and socio-demographic, clinical, and epidemiological characteristics were investigated using Poisson regression with robust variance. Prevalence ratio (PR) was used as the measure of association. RESULTS We examined 263 individuals. The prevalence of LTBI was 40.3%, and the ARI was 2.4%. Age ≥15 years [PR=5.5; 95% confidence interval (CI): 3.5-8.6], contact with tuberculosis (TB) patients (PR=3.8; 95% CI: 1.2-11.9), previous TB history (PR=1.4; 95% CI: 1.2-1.7), and presence of Bacillus Calmette-Guérin (BCG) scar (PR=1.9, 95% CI: 1.2-2.9) were associated with LTBI. CONCLUSIONS Although some adults may have been infected years prior, the high prevalence of infection and its strong association with age ≥15 years, history of TB, and recent contact with TB patients suggest that the TB transmission risk is high in the study area.
dc.identifier.citationMALACARNE, Jocieli; RIOS, Diana Patricia Giraldo; SILVA, Cosme Marcelo Furtado Passos da; BRAGA, José Ueleres; CAMACHO, Luiz Antonio Bastos; BASTA, Paulo Cesar. Prevalence and factors associated with latent tuberculosis infection in an indigenous population in the Brazilian Amazon. Revista da Sociedade Brasileira de Medicina Tropical, v. 49, n. 4, p. 456-464, 2016.
dc.identifier.doi10.1590/0037-8682-0220-2016
dc.identifier.issn0037-8682
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/1039
dc.language.isopor
dc.publisherSociedade Brasileira de Medicina Tropical - SBMTen_US
dc.rightsopen accessen_US
dc.subject.otherBrasil
dc.subject.otherÍndios Sul-Americanos
dc.subject.otherRegião Norte
dc.subject.otherRegião Amazônica
dc.subject.otherEpidemiologia
dc.subject.otherRondônia
dc.subject.otherTuberculose
dc.subject.otherPakaanova
dc.subject.otherServiços de Saúde
dc.subject.otherEstudos Epidemiológicos
dc.subject.otherWari´
dc.subject.otherRadiografia
dc.subject.otherDesigualdades em Saúde
dc.subject.otherDoenças Infecciosas e Parasitárias
dc.subject.otherSaúde de Populações Indígenas
dc.subject.otherCondições Socioeconômicas
dc.subject.otherTeste Tuberculínico
dc.subject.otherExame Radiológico
dc.titlePrevalence and factors associated with latent tuberculosis infection in an indigenous population in the Brazilian Amazonen_US
dc.typeArticleen_US
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