Restriction and persistence of polymorphisms of HLA and other blood genetic traits in the Parakanã Indians of Brazil
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restricted access
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Article
Date
1980
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Wiley
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Yale University School of Medicine. Department of Epidemiology and Public Health. New Haven, CT, USA.
Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil.
Instituto Venezolano de Investigaciones Científicas. Caracas, Venezuela.
Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil.
Yale University School of Medicine. Department of Epidemiology and Public Health. New Haven, CT, USA.
Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil.
Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil.
Instituto Venezolano de Investigaciones Científicas. Caracas, Venezuela.
Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil.
Yale University School of Medicine. Department of Epidemiology and Public Health. New Haven, CT, USA.
Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil.
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Abstract
Abstract
Results concerning HLA types and 22 other blood genetic systems are reported for the Parakanã Indians of northern Brazil, a tribe that is notable for the light color and pilosity of some of its members. No clear evidence of Caucasoid admixture was found, but the Parkanã show unusual frequencies in the EsD¹, PGM¹₁, Gc², Cpᴮ, Fyᵃ, Diᵃ, and Lᴹ genetic markers. In addition, the very rare Rh allele rʸ is present, as well as what seems to be a new PGM₂ variant. There is very limited heterogeneity in the HLA system. All these distinctive features may have arisen through a combination of founder effects and genetic drift. However, low Fᵢₛ values, as well as higher mean ages in heterozygous as compared to homozygous persons, suggest that an heterotic effect is counteracting these dispersive forces.
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Keywords in Portuguese
Região Norte, Parakanã, Grupo Sanguíneo
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DeCS
Brasil, Índios Sul-Americanos, Saúde de Populações Indígenas, Antígenos HLA, Enzimas, Antígenos de Grupos Sanguíneos, Proteínas Sanguíneas
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BLACK, Francis L. et al. Restriction and persistence of polymorphisms of HLA and other blood genetic traits in the Parakanã Indians of Brazil. American Journal of Physical Anthropology, v. 52, n. 1, p. 119-132, Jan. 1980.
ISBN
ISSN
0002-9483
DOI
10.1002/ajpa.1330520115