Platelet alloantigen frequencies in Amazon Indians and Brazilian blood donors

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dc.contributor.authorChiba, A. K.
dc.contributor.authorBordin, J. O.
dc.contributor.authorKuwano, S. T.
dc.contributor.authorFigueiredo, M. S.
dc.contributor.authorCarvalho, K. I.
dc.contributor.authorVieira Filho, João Paulo B.
dc.contributor.authorKerbauy, J.
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasilen_US
dc.date.accessioned2019-10-15T12:56:42Z
dc.date.available2019-10-15T12:56:42Z
dc.date.issued2000
dc.description.abstractenThe frequencies of human platelet-specific alloantigens (HPAs) vary between different ethnic groups, and genotyping using DNA techniques has been preferred over immunophenotyping methods for population studies. Using a polymerase chain reaction with allele-specific primers (PCR-ASP) method, we determined the allelic polymorphisms of five HPA systems among 174 unrelated individuals of two different Brazilian ethnic groups including Amazon Indians (n = 95) and blood donors (n = 79). Comparison of the calculated gene frequencies of the two alleles of HPA-1, -2, -3, -4 and -5 systems for Amazon Indians and Brazilian blood donors showed that gene frequencies obtained for the two alleles of HPA-1 (P<0.001), HPA-2 (P = 0.001) and HPA-5 (P<0.001) were significantly different between the two groups of individuals. All natives tested carried the HPA-2a and the HPA-5a alleles, but the HPA-1b and HPA-4b alleles are absent from the Indian population. It was also observed that all blood donors carried the HPA-1a, HPA-4a and HPA-5a alleles. In conclusion, the present data indicate differences in the frequency of the HPA systems between Amazon Indians and Brazilian subjects who present a high rate of racial admixture. While the frequencies of the HPA-1 and HPA-5 genes seen in Amazon Indians are similar to those reported for Oriental populations, the frequencies of the HPAs alleles in Brazilian blood donors are comparable to those reported for populations in North America and Europe.en_US
dc.identifier.citationCHIBA, A. K.. et al. Platelet alloantigen frequencies in Amazon Indians and Brazilian blood donors. Transfusion Medicine, v. 10, n. 3, p. 207-212, 2000.en_US
dc.identifier.issn0958-7578
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/1269
dc.language.isoeng
dc.publisherWileyen_US
dc.rightsopen accessen_US
dc.subject.decsBrasilen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsEcossistema Amazônicoen_US
dc.subject.decsEpidemiologiaen_US
dc.subject.decsGenética Humanaen_US
dc.subject.decsGenótipoen_US
dc.subject.otherBrasilen_US
dc.subject.otherÍndios Sul-Americanosen_US
dc.subject.otherRegião Norteen_US
dc.subject.otherSaúde de Populações Indígenasen_US
dc.subject.otherRegião Amazônicaen_US
dc.subject.otherEpidemiologiaen_US
dc.subject.otherParáen_US
dc.subject.otherXikrinen_US
dc.subject.otherKaiapóen_US
dc.subject.otherGenética Humanaen_US
dc.subject.otherGenótipoen_US
dc.subject.otherXikrin-Kayapoen_US
dc.titlePlatelet alloantigen frequencies in Amazon Indians and Brazilian blood donorsen_US
dc.typeArticleen_US
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