Platelet alloantigen frequencies in Amazon Indians and Brazilian blood donors
Copyright
open access
Type
Article
Date
2000
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Alternative Title
Affilliation
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil
Advisor
Co-Advisor
Committee Member
Organizer
Coordinator(s)
Institutional author
Director
item.page.production
Screenplay
Producer
Recorder
Abstract
Abstract
The frequencies of human platelet-specific alloantigens (HPAs) vary between different ethnic groups, and genotyping using DNA techniques has been preferred over immunophenotyping methods for population studies. Using a polymerase chain reaction with allele-specific primers (PCR-ASP) method, we determined the allelic polymorphisms of five HPA systems among 174 unrelated individuals of two different Brazilian ethnic groups including Amazon Indians (n = 95) and blood donors (n = 79). Comparison of the calculated gene frequencies of the two alleles of HPA-1, -2, -3, -4 and -5 systems for Amazon Indians and Brazilian blood donors showed that gene frequencies obtained for the two alleles of HPA-1 (P<0.001), HPA-2 (P = 0.001) and HPA-5 (P<0.001) were significantly different between the two groups of individuals. All natives tested carried the HPA-2a and the HPA-5a alleles, but the HPA-1b and HPA-4b alleles are absent from the Indian population. It was also observed that all blood donors carried the HPA-1a, HPA-4a and HPA-5a alleles. In conclusion, the present data indicate differences in the frequency of the HPA systems between Amazon Indians and Brazilian subjects who present a high rate of racial admixture. While the frequencies of the HPA-1 and HPA-5 genes seen in Amazon Indians are similar to those reported for Oriental populations, the frequencies of the HPAs alleles in Brazilian blood donors are comparable to those reported for populations in North America and Europe.
Abstract in Spanish
Abstract in French
Description
Keywords in Portuguese
Brasil, Índios Sul-Americanos, Região Norte, Saúde de Populações Indígenas, Região Amazônica, Epidemiologia, Pará, Xikrin, Kaiapó, Genética Humana, Genótipo, Xikrin-Kayapo
Keywords
Keywords in Spanish
Keywords in French
DeCS
Brasil, Saúde de Populações Indígenas, Índios Sul-Americanos, Ecossistema Amazônico, Epidemiologia, Genética Humana, Genótipo
Event Date
Previous version
Related Document
Means of dissemination
Duration
Duration
Original color system
Target audience context
Audience occupation
Educational Description
Evaluation
Peer Reviewed
Publication Status
Sponsorship
Latest version
Version
Event Location
Event title
Event Type
Citation
CHIBA, A. K.. et al. Platelet alloantigen frequencies in Amazon Indians and Brazilian blood donors. Transfusion Medicine, v. 10, n. 3, p. 207-212, 2000.
ISBN
ISSN
0958-7578