Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians

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dc.contributor.authorFujiyoshi, Toshinobu
dc.contributor.authorYashiki, Shinji
dc.contributor.authorFujiyama, Chihaya
dc.contributor.authorKuwayama, Masahiro
dc.contributor.authorMiyashita, Hiroki
dc.contributor.authorOhnishi, Hiroshi
dc.contributor.authorBlank, Michelle
dc.contributor.authorZaninovic, Vladimir
dc.contributor.authorBlank, Abraham
dc.contributor.authorCartier, Luis
dc.contributor.authorByrnes, John J.
dc.contributor.authorHarrington Jr., William J.
dc.contributor.authorMiura, Tomoyuki
dc.contributor.authorHayami, Masanori
dc.contributor.authorTajima, Kazuo
dc.contributor.authorSonoda, Shunro
dc.creator.affilliationKagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan.en_US
dc.creator.affilliationKagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan.en_US
dc.creator.affilliationKagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan.en_US
dc.creator.affilliationKagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan.en_US
dc.creator.affilliationKagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan.en_US
dc.creator.affilliationSumitomo Metal Industries. Bio-medical Division. Tokyo, Japan.en_US
dc.creator.affilliationKagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan.en_US
dc.creator.affilliationUniversity of Valle. Faculty of Medicine. Department of Clinical Neurology. Cali, Colombia.en_US
dc.creator.affilliationUniversity of Valle. Cell Biology Division. Cali, Colombia.en_US
dc.creator.affilliationUniversity of Chile. Faculty of Medicine. Department of Neurology. Santiago, Chile.en_US
dc.creator.affilliationUniversity of Miami. Miami, FL, USA.en_US
dc.creator.affilliationUniversity of Miami. Miami, FL, USA.en_US
dc.creator.affilliationKyoto University. Institute for Virus Research. Kyoto, Japan.en_US
dc.creator.affilliationKyoto University. Institute for Virus Research. Kyoto, Japan.en_US
dc.creator.affilliationAichi Cancer Center Research Institute. Division of Epidemiology. Nagoya, Japan.en_US
dc.creator.affilliationKagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan.en_US
dc.date.accessioned2022-06-13T15:54:40Z
dc.date.available2022-06-13T15:54:40Z
dc.date.issued1995
dc.description"To investigate the genetic background of human T-cell leukemia virus type I (HTLV-I) and II (HTLV-IIhd carriers among South American native Indians, we analyzed HLA DRBI*-DQBI bin gdrive log saida TED-SESAI_Coimbra1.csv TED-SESAI_Coimbra2.csv TED-SESAI_Coimbra2.csv.orig xml haplotypes of the virus carriers from Andes highlands and Orinoco lowlands by the PCR-RFLP genotyping method. It was revealed that the HTLV-I-carrying Andes natives had one of the 5 HLA haplotypes: DRBI*-DQBI* 0403-0302, 0802-0402, 0901-0303, 1406-0302 and 0407-0302, and that the Orinoco HTLV-II carriers had one of the 3 HLA haplotypes: DRBI*-DQBI* 1402-0301, 1602-0301 and 0404-0302. The HLA haplotypes of Andes HTLV-I carriers and Orinoco HTLV-II carriers were mutually exclusive. The haplotypes associated with HTLV-I carriers were commonly found among the Andes Indians and Japanese, which is the known HTLV-I endemic population, while the haplotypes associated with HTLV-II carriers were specifically found among the Orinoco Indians and North American Indians, among whom HTLV-II is endemic. These reults suggested that HLA haplotypes might be ethnically segregated among South American natives and might be involved in the susceptibility to HTLV-I and HTLV-II infections."en_US
dc.description.abstractenThd investigate the genetic background of human T-cell leukemia virus type I (HTLV-I) and II (HTLV-IIhd carriers among South American native Indians, we analyzed HLA DRBI*-DQBI * haplotypes of the virus carriers from Andes highlands and Orinoco lowlands by the PCR-RFLP genotyping method. It was revealed that the HTLV-I-carrying Andes natives had one of the 5 HLA haplotypes: DRBI*-DQBI* 0403-0302, 0802-0402, 0901-0303, 1406-0302 and 0407-0302, and that the Orinoco HTLV-II carriers had one of the 3 HLA haplotypes: DRBI*-DQBI* 1402-0301, 1602-0301 and 0404-0302. The HLA haplotypes of Andes HTLV-I carriers and Orinoco HTLV-II carriers were mutually exclusive. The haplotypes associated with HTLV-I carriers were commonly found among the Andes Indians and Japanese, which is the known HTLV-I endemic population, while the haplotypes associated with HTLV-II carriers were specifically found among the Orinoco Indians and North American Indians, among whom HTLV-II is endemic. These reults suggested that HLA haplotypes might be ethnically segregated among South American natives and might be involved in the susceptibility to HTLV-I and HTLV-II infections.en_US
dc.identifier.citationFUJIYOSHI, Toshinobu et al. Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians. International Journal of Cancer, v. 63, n. 4, p. 510-515, 15 nov. 1995.en_US
dc.identifier.doi10.1002/ijc.2910630409
dc.identifier.eissn1097-0215
dc.identifier.issn0020-7136
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/7067
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsrestricted accessen_US
dc.titleEthnic segregation of HTLV-I and HTLV-II carriers among South American native Indiansen_US
dc.typeArticleen_US
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