Genome-wide analysis in Brazilian Xavante Indians reveals low degree of admixture
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open access
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2012
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Public Library of Science
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Universidade Federal de São Paulo. Escola Paulista de Medicina. Disciplina de Endocrinologia. São Paulo, SP, Brasil
Universidade de São Paulo. Escola de Medicina. Instituto do Coração. São Paulo, SP, Brasil
Universidade de São Paulo. Escola de Medicina. Instituto do Coração. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. Disciplina de Endocrinologia. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. Disciplina de Endocrinologia. São Paulo, SP, Brasil
Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Social. Ribeirão Preto, SP, Brasil
Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Social. Ribeirão Preto, SP, Brasil
Universidade de São Paulo. Escola de Medicina. Instituto do Coração. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. Disciplina de Endocrinologia. São Paulo, SP, Brasil
Universidade de São Paulo. Escola de Medicina. Instituto do Coração. São Paulo, SP, Brasil
Universidade de São Paulo. Escola de Medicina. Instituto do Coração. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. Disciplina de Endocrinologia. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. Disciplina de Endocrinologia. São Paulo, SP, Brasil
Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Social. Ribeirão Preto, SP, Brasil
Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Social. Ribeirão Preto, SP, Brasil
Universidade de São Paulo. Escola de Medicina. Instituto do Coração. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. Disciplina de Endocrinologia. São Paulo, SP, Brasil
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Abstract
Abstract
Characterization of population genetic variation and structure can be used as tools for research in human genetics and population isolates are of great interest. The aim of the present study was to characterize the genetic structure of Xavante Indians and compare it with other populations. The Xavante, an indigenous population living in Brazilian Central Plateau, is one of the largest native groups in Brazil. A subset of 53 unrelated subjects was selected from the initial sample of 300 Xavante Indians. Using 86,197 markers, Xavante were compared with all populations of HapMap Phase III and HGDP-CEPH projects and with a Southeast Brazilian population sample to establish its population structure. Principal Components Analysis showed that the Xavante Indians are concentrated in the Amerindian axis near other populations of known Amerindian ancestry such as Karitiana, Pima, Surui and Maya and a low degree of genetic admixture was observed. This is consistent with the historical records of bottlenecks experience and cultural isolation. By calculating pair-wise F(st) statistics we characterized the genetic differentiation between Xavante Indians and representative populations of the HapMap and from HGDP-CEPH project. We found that the genetic differentiation between Xavante Indians and populations of Ameridian, Asian, European, and African ancestry increased progressively. Our results indicate that the Xavante is a population that remained genetically isolated over the past decades and can offer advantages for genome-wide mapping studies of inherited disorders.
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Brasil, Índios Sul-Americanos, Saúde de Populações Indígenas, Mato Grosso, Região Amazônica, Epidemiologia, Região Centro-Oeste, Xavante, Genética Humana
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Brasil, Saúde de Populações Indígenas, Índios Sul-Americanos, Ecossistema Amazônico, Epidemiologia, Genética Humana
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KUHN, Patricia C. et al. Genome-wide analysis in Brazilian Xavante Indians reveals low degree of admixture. Plos One, v. 7, n. 8, p. e42702, 2012.
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10.1371/journal.pone.0042702