Genome-wide analysis in Brazilian Xavante Indians reveals low degree of admixture

dc.contributor.authorKuhn, Patricia C.
dc.contributor.authorHorimoto, Andréa R. V. Russo
dc.contributor.authorSanches, José Maurício
dc.contributor.authorVieira Filho, João Paulo B.
dc.contributor.authorFranco, Luciana
dc.contributor.authorFabbro, Amaury Dal
dc.contributor.authorFranco, Laercio Joel
dc.contributor.authorPereira, Alexandre C.
dc.contributor.authorMoises, Regina S.
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. Disciplina de Endocrinologia. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. Disciplina de Endocrinologia. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. Disciplina de Endocrinologia. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Social. Ribeirão Preto, SP, Brasilen_US
dc.creator.affilliationUniversidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Social. Ribeirão Preto, SP, Brasilen_US
dc.creator.affilliationUniversidade de São Paulo. Escola de Medicina. Instituto do Coração. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. Disciplina de Endocrinologia. São Paulo, SP, Brasilen_US
dc.date.accessioned2019-10-15T14:24:21Z
dc.date.available2019-10-15T14:24:21Z
dc.date.issued2012
dc.description.abstractenCharacterization of population genetic variation and structure can be used as tools for research in human genetics and population isolates are of great interest. The aim of the present study was to characterize the genetic structure of Xavante Indians and compare it with other populations. The Xavante, an indigenous population living in Brazilian Central Plateau, is one of the largest native groups in Brazil. A subset of 53 unrelated subjects was selected from the initial sample of 300 Xavante Indians. Using 86,197 markers, Xavante were compared with all populations of HapMap Phase III and HGDP-CEPH projects and with a Southeast Brazilian population sample to establish its population structure. Principal Components Analysis showed that the Xavante Indians are concentrated in the Amerindian axis near other populations of known Amerindian ancestry such as Karitiana, Pima, Surui and Maya and a low degree of genetic admixture was observed. This is consistent with the historical records of bottlenecks experience and cultural isolation. By calculating pair-wise F(st) statistics we characterized the genetic differentiation between Xavante Indians and representative populations of the HapMap and from HGDP-CEPH project. We found that the genetic differentiation between Xavante Indians and populations of Ameridian, Asian, European, and African ancestry increased progressively. Our results indicate that the Xavante is a population that remained genetically isolated over the past decades and can offer advantages for genome-wide mapping studies of inherited disorders.en_US
dc.identifier.citationKUHN, Patricia C. et al. Genome-wide analysis in Brazilian Xavante Indians reveals low degree of admixture. Plos One, v. 7, n. 8, p. e42702, 2012.en_US
dc.identifier.doi10.1371/journal.pone.0042702
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/1276
dc.language.isoeng
dc.publisherPublic Library of Scienceen_US
dc.rightsopen accessen_US
dc.subject.decsBrasilen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsEcossistema Amazônicoen_US
dc.subject.decsEpidemiologiaen_US
dc.subject.decsGenética Humanaen_US
dc.subject.otherBrasilen_US
dc.subject.otherÍndios Sul-Americanosen_US
dc.subject.otherSaúde de Populações Indígenasen_US
dc.subject.otherMato Grossoen_US
dc.subject.otherRegião Amazônicaen_US
dc.subject.otherEpidemiologiaen_US
dc.subject.otherRegião Centro-Oesteen_US
dc.subject.otherXavanteen_US
dc.subject.otherGenética Humanaen_US
dc.titleGenome-wide analysis in Brazilian Xavante Indians reveals low degree of admixtureen_US
dc.typeArticleen_US
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