Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors

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dc.contributor.authorTavares, Edelweiss F.
dc.contributor.authorVieira-Filho, João P. B.
dc.contributor.authorAndriolo, Adagmar
dc.contributor.authorPerez, Ana B. A.
dc.contributor.authorVergani, Naja
dc.contributor.authorSañudo, Adriana
dc.contributor.authorGimeno, Suely G. A.
dc.contributor.authorFranco, Laércio J.
dc.date.accessioned2021-11-23T13:22:46Z
dc.date.available2021-11-23T13:22:46Z
dc.date.issued2004
dc.description.abstractenHyperhomocysteinemia is a risk factor for cardiovascular disease. C677T mutation at the MTHFR gene and deficiencies of folic acid and vitamin B-12 may account for elevation of total homocysteine (tHcy). Ninety Brazilian Parkateˆjeˆ Indians (90.0% of the population without admixture, aged $20 years) were studied. Hyperhomocysteinemia was observed in 26.7% of the Indians. No case of vitamin B-12 deficiency was detected. Folic acid deficiency was found in 43.3% of the subjects. Rates of mutated allele 677T and TT genotype were 40.7% and 14.0%, respectively. Prevalence of hypertension, dyslipidemia, smoking, WHR $0.9, BMI $25 kg/m2 and chronic alcohol use were 4.4%, 44.4%, 25.6%, 72.2%, 67.8%, and 0.0%, respectively. All creatinine values were normal. Natural logarithmic (ln) tHcy showed no correlation with age, but was positively correlated with systolic (r50.22) and diastolic (r50.21) blood pressure and triglycerides (r50.39) and inversely correlated with folic acid (r520.40) adjusted for age and sex. Total homocysteine (tHcy) was higher among TT genotype (P,.001). The multiple linear regression model, containing variables for sex, folic acid, TT genotype, and triglycerides, explained 50.0% of the variation of the ln tHcy. In summary, high rates of cardiovascular risk factors were discovered. C667T mutation and folic acid deficiency can explain, at least in part, the observed hyperhomocysteinemiaen_US
dc.identifier.citationTAVARES, Edelweiss F.; et al. Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors. Ethnicity & Disease, v. 14, n. 1, p. 49-56, 2004.en_US
dc.identifier.issn1049-510X
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/5271
dc.language.isoengen_US
dc.publisherEthnicity and Disease, Incen_US
dc.rightsopen accessen_US
dc.subject.decsBrasilen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsEpidemiologiaen_US
dc.subject.decsDoenças Cardiovascularesen_US
dc.subject.decsDeficiências Nutricionaisen_US
dc.subject.decsDislipidemiasen_US
dc.subject.decsAntropometriaen_US
dc.subject.decsVitamina B 12en_US
dc.subject.decsDeficiência de Ácido Fólicoen_US
dc.subject.otherRegião Norteen_US
dc.subject.otherRegião Amazônicaen_US
dc.subject.otherParáen_US
dc.subject.otherParkatêjêen_US
dc.subject.otherGenética Humanaen_US
dc.titleSerum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factorsen_US
dc.typeArticleen_US
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