Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors
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2004
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Ethnicity and Disease, Inc
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Affilliation
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Abstract
Abstract
Hyperhomocysteinemia is a risk factor for
cardiovascular disease. C677T mutation at the
MTHFR gene and deficiencies of folic acid and
vitamin B-12 may account for elevation of total
homocysteine (tHcy). Ninety Brazilian Parkateˆjeˆ Indians (90.0% of the population without
admixture, aged $20 years) were studied. Hyperhomocysteinemia was observed in 26.7%
of the Indians. No case of vitamin B-12 deficiency was detected. Folic acid deficiency was
found in 43.3% of the subjects. Rates of mutated allele 677T and TT genotype were 40.7%
and 14.0%, respectively. Prevalence of hypertension, dyslipidemia, smoking, WHR $0.9,
BMI $25 kg/m2 and chronic alcohol use were
4.4%, 44.4%, 25.6%, 72.2%, 67.8%, and
0.0%, respectively. All creatinine values were
normal. Natural logarithmic (ln) tHcy showed
no correlation with age, but was positively correlated with systolic (r50.22) and diastolic
(r50.21) blood pressure and triglycerides
(r50.39) and inversely correlated with folic
acid (r520.40) adjusted for age and sex. Total
homocysteine (tHcy) was higher among TT genotype (P,.001). The multiple linear regression model, containing variables for sex, folic
acid, TT genotype, and triglycerides, explained
50.0% of the variation of the ln tHcy. In summary, high rates of cardiovascular risk factors
were discovered. C667T mutation and folic
acid deficiency can explain, at least in part, the
observed hyperhomocysteinemia
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Região Norte, Região Amazônica, Pará, Parkatêjê, Genética Humana
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Brasil, Saúde de Populações Indígenas, Índios Sul-Americanos, Epidemiologia, Doenças Cardiovasculares, Deficiências Nutricionais, Dislipidemias, Antropometria, Vitamina B 12, Deficiência de Ácido Fólico
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TAVARES, Edelweiss F.; et al. Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors. Ethnicity & Disease, v. 14, n. 1, p. 49-56, 2004.
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1049-510X