Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes

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dc.contributor.authorJacovas, Vanessa Cristina
dc.contributor.authorRovaris, Diego Luiz
dc.contributor.authorPeréz, Orlando
dc.contributor.authorAzevedo, Soledad de
dc.contributor.authorMacedo, Gabriel Souza
dc.contributor.authorSandoval, José Raul
dc.contributor.authorSalazar-Granara, Alberto
dc.contributor.authorVillena, Mercedes
dc.contributor.authorDugoujon, Jean-Michel
dc.contributor.authorBisso-Machado, Rafael
dc.contributor.authorPetzl-Erler, Maria Luiza
dc.contributor.authorSalzano, Francisco M.
dc.contributor.authorAshton-Prolla, Patricia
dc.contributor.authorRamallo, Virginia
dc.contributor.authorBortolini, Maria Cátira
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS Brasilen_US
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS Brasilen_US
dc.creator.affilliationConsejo Nacional de Investigaciones Científicas y Tecnológicas - CONICET. Puerto Madryn, Argentinaen_US
dc.creator.affilliationConsejo Nacional de Investigaciones Científicas y Tecnológicas - CONICET. Puerto Madryn, Argentinaen_US
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS Brasilen_US
dc.creator.affilliationFacultad de Medicina Humana. Universidad de San Martin de Porres. Lima, Peruen_US
dc.creator.affilliationFacultad de Medicina Humana. Universidad de San Martin de Porres. Lima, Peruen_US
dc.creator.affilliationUniversidad Mayor de San Andres. Instituto Boliviano de Biología de Altura. La Paz, Bolíviaen_US
dc.creator.affilliationUniversité Paul Sabatier Toulouse III. Anthropologie Moléculaire et Imagerie de Synthèse. Toulouse, Franceen_US
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS Brasilen_US
dc.creator.affilliationUniversidade Federal do Paraná. Departamento de Genética. Laboratório de Genética Molecular. Curitiba, PR, Brasil.en_US
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS Brasil /en_US
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS Brasil / Hospital de Clínicas de Porto Alegre. Serviço de Genética Medica. Porto Alegre, RS, Brasilen_US
dc.creator.affilliationConsejo Nacional de Investigaciones Científicas y Tecnológicas - CONICET. Puerto Madryn, Argentinaen_US
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS Brasilen_US
dc.date.accessioned2019-09-26T18:27:52Z
dc.date.available2019-09-26T18:27:52Z
dc.date.issued2015
dc.description.abstractThe diversity of the five single nucleotide polymorphisms located in genes of the TP53 pathway (TP53, rs1042522; MDM2, rs2279744; MDM4, rs1563828; USP7, rs1529916; and LIF, rs929271) were studied in a total of 282 individuals belonging to Quechua, Aymara, Chivay, Cabanaconde, Yanke, Taquile, Amantani, Anapia, Uros, Guarani Ñandeva, and Guarani Kaiowá populations, characterized as Native American or as having a high level (> 90%) of Native American ancestry. In addition, published data pertaining to 100 persons from five other Native American populations (Surui, Karitiana, Maya, Pima, and Piapoco) were analyzed. The populations were classified as living in high altitude (≥ 2,500 m) or in lowlands (< 2,500 m). Our analyses revealed that alleles USP7-G, LIF-T, and MDM2-T showed significant evidence that they were selected for in relation to harsh environmental variables related to high altitudes. Our results show for the first time that alleles of classical TP53 network genes have been evolutionary co-opted for the successful human colonization of the Andes.en_US
dc.identifier.citationJACOVAS, Vane. et al. Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes. Plos One, v. 10, n. 9, p. 1-15, 2015.en_US
dc.identifier.doi10.1371/journal.pone.0137823
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/1109
dc.language.isoeng
dc.publisherPLOSen_US
dc.rightsopen accessen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsGenética Populacionalen_US
dc.subject.decsGenética Humanaen_US
dc.subject.decsProteínas Proto-Oncogênicas c-mdm2en_US
dc.subject.otherÍndios Sul-Americanosen_US
dc.subject.otherSaúde de Populações Indígenasen_US
dc.subject.otherGenética Populacionalen_US
dc.subject.otherProteínas Proto-Oncogênicas c-mdm2en_US
dc.titleGenetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andesen_US
dc.typeArticleen_US
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