Cytokine genes are associated with tuberculin skin test response in a native Brazilian population

Simple item page
dc.contributor.authorZembrzuski, Verônica M.
dc.contributor.authorBasta, Paulo Cesar
dc.contributor.authorCallegari-Jacques, S. M.
dc.contributor.authorSantos, Ricardo Ventura
dc.contributor.authorCoimbra Junior, Carlos Everaldo Alvares
dc.contributor.authorSalzano, Francisco M.
dc.contributor.authorHutz, Mara H.
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasilen_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasilen_US
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Departamento de Estatística. Porto Alegre, RS, Brasilen_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasilen_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasilen_US
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasilen_US
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasilen_US
dc.date.accessioned2019-12-05T12:40:01Z
dc.date.available2019-12-05T12:40:01Z
dc.date.issued2010
dc.description.abstractenTuberculosis was a major cause of population decline among Brazilian indigenous peoples and remains a leading cause of morbidity and mortality among them. Despite high BCG coverage, results of Tuberculin Skin Test (TST) reactivity have shown high rates of anergy in Amazonian Indians. Given the high prevalence of anergy in these populations and the fact that genetic host factors play an important role in susceptibility to Mycobacterium tuberculosis (MTB), the aim of this study was to evaluate the association of nineteen polymorphisms in fifteen genes related to immune response and anergy in the Xavante, an indigenous group from Brazil. A total of 481 individuals were investigated. TST anergy was observed in 69% of them. Polymorphisms in four genes showed absence or very low variability: SP110, PTPN22, IL12RB1 and IL6. IFNG +874 A/T heterozygotes and IL4-590 C/C homozygotes were more frequent in those individuals who presented a positive TST (prevalence ratios of 1.9 and 2.0 respectively). The risk of anergy was 1.5 in IL10-1082 G/G homozygotes when compared to carriers for the A allele. In indigenous groups such as the Xavante exposure to a variety of infections, associated with specific genetic factors, may disturb the T-helper 1 and T-helper 2 balance leading to increased immunological susceptibility.en_US
dc.identifier.citationZEMBRZUSKI, Verônica M. et al. Cytokine genes are associated with tuberculin skin test response in a native Brazilian population. Tuberculosis (Edinburgh, Scotland), v. 90, n. 1, p. 44-49, 2010.en_US
dc.identifier.doi10.1016/j.tube.2009.11.002
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/1399
dc.language.isoeng
dc.publisherElsevieren_US
dc.rightsopen accessen_US
dc.subject.decsBrasilen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsEcossistema Amazônicoen_US
dc.subject.decsTuberculoseen_US
dc.subject.decsMorbidadeen_US
dc.subject.decsGenética Humanaen_US
dc.subject.decsMycobacterium tuberculosisen_US
dc.subject.decsEpidemiologiaen_US
dc.subject.decsDoenças Infecciosasen_US
dc.subject.otherBrasilen_US
dc.subject.otherÍndios Sul-Americanosen_US
dc.subject.otherSaúde de Populações Indígenasen_US
dc.subject.otherMato Grossoen_US
dc.subject.otherRegião Amazônicaen_US
dc.subject.otherEpidemiologiaen_US
dc.subject.otherRegião Centro-Oesteen_US
dc.subject.otherXavanteen_US
dc.subject.otherTuberculoseen_US
dc.subject.otherMorbidadeen_US
dc.subject.otherGenética Humanaen_US
dc.subject.otherMycobacterium tuberculosisen_US
dc.subject.otherDoenças Infecciosas e Parasitáriasen_US
dc.titleCytokine genes are associated with tuberculin skin test response in a native Brazilian populationen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
702409066.pdf
Size:
163.21 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description:
Download
Collections
EPI - Artigos de Periódicos