Protracted Outbreak of Severe Delta Hepatitis: Experience in an Isolated Amerindian Population of the Upper Orinoco Basin

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dc.contributor.authorTorres, Jaime R.
dc.contributor.authorMondolfi, Alejandro
dc.creator.affilliationUnlversidade Central de Venezuela. Instituto de Medicina Tropical. Caracas, Venezuelaen_US
dc.creator.affilliationUnlversidade Central de Venezuela. Instituto de Medicina Tropical. Caracas, Venezuelaen_US
dc.date.accessioned2022-01-20T00:23:50Z
dc.date.available2022-01-20T00:23:50Z
dc.date.issued1991
dc.description.abstractenIn an investigation of a 21-year-old epidemic of severe hepatitis, 80 serum samples were studied from two isolated Yanomami Amerindian populations of the Upper Orinoco basin in Venezuela. Of the assayed samples, 30.6% were positive for hepatitis B surface antigen (HBsAg), 53.7% were considered to reflect immunity to infection with hepatitis B virus (HBV), and only 16.2% were believed to reflect susceptibility to HBV infection; 82.5% of the samples tested positive for any marker of HBV infection. Thirty-one (39.7%) of 78 samples were also positive for antibody to delta antigen, including 91.6% of those positive for HBsAg and 20.9% of those immune to HBV. Our findings provide evidence of a high prevalence of HBV infection in this population. Furthermore, the high prevalence of antibody to delta antigen strongly suggests that coinfections with HBV or superinfections with hepatitis delta virus (HDV) in HBV carriers may be an important factor in the occurrence of an unusually high number of cases of fulminant hepatitis and of chronic liver disease. Serum samples obtained at the beginning of the outbreak 13 years earlier from 36 selected cases in the same population revealed a high rate of HBV infection (96.5%). All six HBsAg carriers from whom enough serum remained to be assayed were positive for antibody to delta antigen. Our findings indicate that the outbreak coincided with the introduction of HDV into a population with an already-high prevalence of HBV infection.en_US
dc.identifier.citationTORRES, Jaime R.; MONDOLFI, Alejandro. Protracted Outbreak of Severe Delta Hepatitis: Experience in an Isolated Amerindian Population of the Upper Orinoco Basin. Infectious Diseases, v. 13, n. 1, p. 52-55, 1991.en_US
dc.identifier.issn0162-0886
dc.identifier.issn0162-0886
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/5915
dc.language.isoporen_US
dc.publisherThe Lanceten_US
dc.rightsopen accessen_US
dc.subject.decsBrasilen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsDoenças Infecciosasen_US
dc.subject.decsHepatite Ben_US
dc.subject.decsHepatite Viralen_US
dc.subject.enBrazilen_US
dc.subject.enHealth of Indigenous Peoplesen_US
dc.subject.enIndians, South Americanen_US
dc.subject.enHepatitis Ben_US
dc.subject.enHepatitis, Viral, Humanen_US
dc.subject.otherBrasilen_US
dc.subject.otherÍndios Sul-Americanosen_US
dc.subject.otherSaúde de Populações Indígenasen_US
dc.subject.otherDoenças Infecciosasen_US
dc.subject.otherHepatite Ben_US
dc.subject.otherHepatite Viralen_US
dc.titleProtracted Outbreak of Severe Delta Hepatitis: Experience in an Isolated Amerindian Population of the Upper Orinoco Basinen_US
dc.typeArticleen_US
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