Tuberculosis control in a highly endemic indigenous community in Brazil
Copyright
open access
Type
Article
Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press
Alternative Title
Affilliation
Universidade Federal de Grande Dourados. Hospital Universitário. Dourados, MS, Brasil.
Ministério da Saúde. Fundação Nacional de Saúde. Dourados, MS, Brasil
Universidade Federal de Grande Dourados. Dourados, MS, Brasil
Universidade Federal de Grande Dourados. Dourados, MS, Brasil
Ministério da Saúde. Fundação Nacional de Saúde. Dourados, MS, Brasil
Universidade Federal de Grande Dourados. Dourados, MS, Brasil
Universidade Federal de Grande Dourados. Dourados, MS, Brasil
Advisor
Co-Advisor
Committee Member
Organizer
Coordinator(s)
Institutional author
Director
item.page.production
Screenplay
Producer
Recorder
Abstract
Abstract
In Latin America, indigenous populations have high rates of non-completion of TB treatment and case fatality and have been defined as a priority group for investments. To evaluate TB control, a retrospective cohort study was performed to identify factors predictive of non-completion of treatment and mortality in an indigenous and non-indigenous population between 2002 and 2008 in Dourados, Brazil. A 90% reduction in non-completion of TB treatment was observed in the indigenous population after DOTS (directly observed treatment, short course) implementation (20% vs 2%). In the non-indigenous population, the number of patients not completing TB treatment continued to increase. Non-indigenous TB patients had 4.5 times higher mortality than indigenous TB patients (9% vs 2%). In multivariate analysis, non-indigenous race [odds ratio (OR) 2.33, 95% CI 1.32-4.10] was associated with non-completion of TB treatment, and HIV-positive status (OR 5.58, 95% CI 2.38-13.07) was associated with mortality. Implementation of DOTS in the indigenous populations in Dourados showed a significant reduction in non-completion of TB treatment. Nevertheless, a high rate of TB in children and young adults indicates the continuous transmission and maintenance of the epidemic in this community. Among the non-indigenous population, the TB case fatality rate is closely linked to the HIV prevalence.
Abstract in Spanish
Abstract in French
Description
Keywords in Portuguese
Brasil, Índios Sul-Americanos, Saúde de Populações Indígenas, Epidemiologia, Região Centro-Oeste, Mato Grosso do Sul, Tuberculose, Fatores de Risco, Estudos Epidemiológicos, Doenças Infecciosas
Keywords
Keywords in Spanish
Keywords in French
DeCS
Brasil, Saúde de Populações Indígenas, Índios Sul-Americanos, Epidemiologia, Tuberculose, Fatores de Risco, Doenças Infecciosas, HIV
Event Date
Previous version
Related Document
Means of dissemination
Duration
Duration
Original color system
Target audience context
Audience occupation
Educational Description
Evaluation
Peer Reviewed
Publication Status
Sponsorship
Latest version
Version
Event Location
Event title
Event Type
Citation
CRODA, Mariana Garcia; et al. Tuberculosis control in a highly endemic indigenous community in Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 106, p. 223-229, 2012.
ISBN
ISSN
1878-3503
DOI
10.1016/j.trstmh.2012.01.005