Apolipoprotein B genetic variability in Brazilian Indians
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1999
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Wayne State University Press
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Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brasil
Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brasil
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Departamento de Endemias. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Departamento de Endemias. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Museu Nacional. Departamento de Antropologia. Rio de Janeiro, RJ, Brasil
Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brasil
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Departamento de Endemias. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Departamento de Endemias. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Museu Nacional. Departamento de Antropologia. Rio de Janeiro, RJ, Brasil
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Abstract
Abstract
Three apolipoprotein B restriction fragment length polymorphism (RFLPs) (XbaI, MspI, and EcoRI) and the signal peptide insertion-deletion polymorphism were investigated using the polymerase chain reaction in 140 individuals from 5 Brazilian Indian tribes. All studied markers were polymorphic in this ethnic group. The insertion allele 5' beta SP*29 at the signal peptide previously observed in Mexican Americans was detected in about 8% of the chromosomes of 2 tribes (Gavião and Zoró), therefore confirming the Amerindian origin of this allele. Negative linkage disequilibrium was observed between alleles at the signal peptide and the EcoRI polymorphism in all tribes. In 3 populations (Gavião, Suruí, and Zoró) a negative disequilibrium was also detected between the insertion-deletion signal peptide markers and the XbaI polymorphism. In the whole sample of Amerindians 14 of the 24 (58%) possible 4-marker extended haplotypes were identified, but only haplotype 2 (5' beta SP*24/*X+/*M+/*E+) and haplotype 5 (5' beta SP*27/*X-/*M+/*E+) were shared by all tribes. No associations between plasma lipid levels or body mass index and these polymorphisms were observed in this sample.
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Brasil, Região Norte, Saúde de Populações Indígenas, Mato Grosso, Região Centro-Oeste, Região Amazônica, Pará, Região Sul, Região Sudeste, Gavião, Suruí, Rondônia, Xavante, Zoró, Rio Grande do Sul, Wai Wai, Genética Humana, Rio de Janeiro, Indíos Sul-Americanos
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Brasil, Saúde de Populações Indígenas, Índios Sul-Americanos, Ecossistema Amazônico, Genética Humana
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KAUFMAN, Letícia et al. Apolipoprotein B genetic variability in Brazilian Indians. Human Biology, v. 71, n. 1, p. 87-98, 1999.
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187143