Association of the low-density lipoprotein receptor gene with obesity in Native American populations
Copyright
open access
Type
Article
Date
2000
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Alternative Title
Affilliation
Advisor
Co-Advisor
Committee Member
Organizer
Coordinator(s)
Institutional author
Director
item.page.production
Screenplay
Producer
Recorder
Abstract
Abstract
Five low-density lipoprotein receptor gene (LDLR) restriction fragment length polymorphisms (RFLPs: TaqI, intron 4; HincII, exon 12; AvaII, exon 13; MspI and NcoI, exon 18) were investigated in 131 individuals from five Brazilian Indian tribes. All markers were polymorphic in this ethnic group. In the whole sample of Amerindians, 13 (41%) of the 32 expected haplotypes were identified, but only three were shared by all tribes. The Xavante, Suruí, Zoró, and Gavião tribes, who had been studied for anthropometry, were grouped according to their genotypes, and the corresponding mean values were examined. Significant associations were observed between HincII *H-, AvaII *A+, MspI *M-, and NcoI *N+ and the body mass index (BMI), triceps and subscapular skinfolds, and the arm fat index (AFI). Haplotypes were derived for these four RFLPs, and (*H-/*A+/*M-/*N+) haplotype carriers were compared with noncarriers of this haplotype with equally significant results for the three parameters (BMI, P=0.021; skinfold thickness, P<0.001; AFI, P=0.005). These results suggest that the LDLR gene has some influence over adipose tissue deposition
Abstract in Spanish
Abstract in French
Description
Keywords in Portuguese
Região Norte, Mato Grosso, Região Amazônica, Pará, Região Centro-Oeste, Gavião, Suruí, Rondônia, Xavante, Zoró, Wai Wai
Keywords
Brazil, Health of Indigenous Peoples, Indians, South American, Epidemiology, Human Genetics, Anthropometry, Overweight, Obesity
Keywords in Spanish
Keywords in French
DeCS
Brasil, Saúde de Populações Indígenas, Índios Sul-Americanos, Epidemiologia, Antropometria, Genética Humana, Sobrepeso, Obesidade
Event Date
Previous version
Related Document
Means of dissemination
Duration
Duration
Original color system
Target audience context
Audience occupation
Educational Description
Evaluation
Peer Reviewed
Publication Status
Sponsorship
Latest version
Version
Event Location
Event title
Event Type
Citation
MATTEVI, Vanessa S.; COIMBR JR., Carlos E. A.; SANTOS, Ricardo Ventura; SALZANO, Francisco M.; HUTZ, Mara H.. Association of the low-density lipoprotein receptor gene with obesity in Native American populations. Human Genetics, v. 106, p. 546-552, 2000.
ISBN
ISSN
DOI
10.1007/s004390000299