Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review

dc.contributor.authorLonghi, Renata Maronna Praça
dc.contributor.authorZembrzuski, Verônica Marques
dc.contributor.authorBasta, Paulo Cesar
dc.contributor.authorCroda, Julio Henrique Rosa
dc.creator.affilliationUniversidade Federal da Grande Dourados. Faculty of Health Sciences. Dourados, MS, Brasilen_US
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Universidade Grande Rio. Escola de Ciências da Saúde. Duque de Caxias, RJ, Brasilen_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.en_US
dc.creator.affilliationUniversidade Federal da Grande Dourados. Faculty of Health Sciences. Dourados, MS, Brasil / Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.en_US
dc.date.accessioned2019-10-04T19:49:31Z
dc.date.available2019-10-04T19:49:31Z
dc.date.issued2013
dc.description.abstractenWe systematically reviewed studies of the immune response to tuberculosis and the genetic polymorphisms associated with Th1-or Th2-mediated cytokine expression in indigenous populations. A bibliographic search was performed on the Medline and ISI databases and included studies published between January 1980 and October 2011. The search terms were tuberculosis, American Indians, Amerindian, indigenous, Indians, native people, aboriginal, immun*, host immune, immune response, cytokine*, polymorphism*, and gene. Regardless of their design, studies that evaluated immunoglobulin, cytokine levels and genetic polymorphisms that altered cytokine expression were included. Thirteen studies met the inclusion criteria. The majority of studies were performed in Latin America, and five investigated the Warao ethnic group of Venezuela. Most of the investigations indirectly evaluated the immune response. Higher anergy to the tuberculin skin test, higher IgG4 and IgM levels, higher IL-5 production and lower TNF-a, IL-12p40 and IFN-I production were found in the indigenous populations. The studies also reported a predominantly Th2-type response in these populations and a possibly higher susceptibility to tuberculosis. A better understanding of the relevant genetic polymorphisms and their role in immune regulation would help to clarify the immunogenetic mechanisms of TB infection in these populations. This information would be useful for identifying new treatments and preventing infection and progression to active disease.en_US
dc.identifier10.1016/j.bjid.2012.11.001
dc.identifier1413-8670
dc.identifier.citationLONGHI, Renata Maronna Praça. et al. Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review. The Brazilian Journal of Infectious Diseases, v. 17, n. 3, p. 363-368, 2013.en_US
dc.identifier.doi10.1016/j.bjid.2012.11.001
dc.identifier.issn1413-8670
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/1167
dc.language.isoeng
dc.publisherBrazilian Society of Infectious Diseasesen_US
dc.rightsopen accessen_US
dc.subject.decsBrasilen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsEpidemiologiaen_US
dc.subject.decsTuberculoseen_US
dc.subject.decsDoenças Infecciosasen_US
dc.subject.decsGenética Humanaen_US
dc.subject.decsSistema Imunitárioen_US
dc.subject.otherBrasilen_US
dc.subject.otherÍndios Sul-Americanosen_US
dc.subject.otherSaúde de Populações Indígenasen_US
dc.subject.otherEpidemiologiaen_US
dc.subject.otherTuberculoseen_US
dc.subject.otherRevisãoen_US
dc.subject.otherEstudos Epidemiológicosen_US
dc.subject.otherGenética Humanaen_US
dc.subject.otherDoenças Infecciosas e Parasitáriasen_US
dc.subject.otherSistema Imunológicoen_US
dc.titleGenetic polymorphism and immune response to tuberculosis in indigenous populations: a brief reviewen_US
dc.typeArticleen_US
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