Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review

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open access
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Article
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2013
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Brazilian Society of Infectious Diseases
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Universidade Federal da Grande Dourados. Faculty of Health Sciences. Dourados, MS, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Universidade Grande Rio. Escola de Ciências da Saúde. Duque de Caxias, RJ, Brasil
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.
Universidade Federal da Grande Dourados. Faculty of Health Sciences. Dourados, MS, Brasil / Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.
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Abstract
Abstract
We systematically reviewed studies of the immune response to tuberculosis and the genetic polymorphisms associated with Th1-or Th2-mediated cytokine expression in indigenous populations. A bibliographic search was performed on the Medline and ISI databases and included studies published between January 1980 and October 2011. The search terms were tuberculosis, American Indians, Amerindian, indigenous, Indians, native people, aboriginal, immun*, host immune, immune response, cytokine*, polymorphism*, and gene. Regardless of their design, studies that evaluated immunoglobulin, cytokine levels and genetic polymorphisms that altered cytokine expression were included. Thirteen studies met the inclusion criteria. The majority of studies were performed in Latin America, and five investigated the Warao ethnic group of Venezuela. Most of the investigations indirectly evaluated the immune response. Higher anergy to the tuberculin skin test, higher IgG4 and IgM levels, higher IL-5 production and lower TNF-a, IL-12p40 and IFN-I production were found in the indigenous populations. The studies also reported a predominantly Th2-type response in these populations and a possibly higher susceptibility to tuberculosis. A better understanding of the relevant genetic polymorphisms and their role in immune regulation would help to clarify the immunogenetic mechanisms of TB infection in these populations. This information would be useful for identifying new treatments and preventing infection and progression to active disease.
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Brasil, Índios Sul-Americanos, Saúde de Populações Indígenas, Epidemiologia, Tuberculose, Revisão, Estudos Epidemiológicos, Genética Humana, Doenças Infecciosas e Parasitárias, Sistema Imunológico
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Brasil, Saúde de Populações Indígenas, Índios Sul-Americanos, Epidemiologia, Tuberculose, Doenças Infecciosas, Genética Humana, Sistema Imunitário
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LONGHI, Renata Maronna Praça. et al. Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review. The Brazilian Journal of Infectious Diseases, v. 17, n. 3, p. 363-368, 2013.
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1413-8670
DOI
10.1016/j.bjid.2012.11.001
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