Alibertia edulis (L.C. Rich.) A.C. Rich - A potent diuretic arising from Brazilian indigenous species

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dc.contributor.authorAquino, Diana Figueiredo de Santana
dc.contributor.authorTirloni, Cleide Adriane Signor
dc.contributor.authorMenegati, Sara Emília Lima Tolouei
dc.contributor.authorCardoso, Claudia Andrea Lima
dc.contributor.authorVieira, Silvia Cristina Heredia
dc.contributor.authorVieira, Maria do Carmo
dc.contributor.authorSimonet, Ana María
dc.contributor.authorMacías, Francisco Antonio
dc.contributor.authorGasparotto, Arquimedes
dc.creator.affilliationFederal University of Grande Dourados. Faculty of Health Sciences. Dourados, MS, Brazilen_US
dc.creator.affilliationFederal University of Grande Dourados. Faculty of Health Sciences. Dourados, MS, Brazilen_US
dc.creator.affilliationFederal University of Grande Dourados. Faculty of Sciences Biological and Environmental. Dourados, MS, Brazilen_US
dc.creator.affilliationState University of Mato Grosso do Sul. Faculty of Chemistry. Research Center in Biodiversity. Dourados, MS, Brazilen_US
dc.creator.affilliationState University of Mato Grosso do Sul. Faculty of Chemistry. Research Center in Biodiversity. Dourados, MS, Brazilen_US
dc.creator.affilliationFederal University of Grande Dourados. Faculty of Agrarian Sciences. Laboratory of Medicinal Plants. Dourados, MS, Brazilen_US
dc.creator.affilliationUniversity of Cádiz. Faculty of Sciences. Department of Organic Chemistry. Cádiz, Spainen_US
dc.creator.affilliationUniversity of Cádiz. Faculty of Sciences. Department of Organic Chemistry. Cádiz, Spainen_US
dc.creator.affilliationUniversity of Cádiz. Faculty of Sciences. Department of Organic Chemistry. Cádiz, Spainen_US
dc.date.accessioned2019-12-15T22:08:53Z
dc.date.available2019-12-15T22:08:53Z
dc.date.issued2017
dc.description.abstractenETHNOPHARMACOLOGICAL RELEVANCE: Although Alibertia edulis (L.C. Rich.) A.C. Rich decoction is used in Brazilian folk medicine due to its possible antihypertensive effect, this species has never been critically investigated as a hypotensive drug. So, the aim of this study was to evaluate the possible hypotensive and antihypertensive effects of the oral administration of Alibertia edulis aqueous extract (AEAE) in normotensive and hypertensive rats, and evaluate its inter-relation with a possible diuretic activity. MATERIAL AND METHODS: Different doses of AEAE (20, 65 and 200mg/kg) were tested on the mean arterial pressure (MAP) of normotensive Wistar rats and after induction of renovascular hypertension (two-kidney, one-clip Goldblatt model). In addition, the diuretic effects of AEAE were compared with hydrochlorothiazide (HCTZ) in an acute and repeated-dose treatment for 7 days. Volume, sodium, potassium, chloride, calcium contents, pH and density were estimated in urine samples collected after 8 or 24h. Plasma sodium, potassium, total protein, urea, creatinine, AST and ALT concentrations were measured in samples collected at the end of the experimental period (seventh day). Finally, the antioxidant activity of the AEAE was assessed using the DPPH radical scavenging and ferric ions reducing power assay. RESULTS: The intraduodenal administration of the HCTZ and AEAE significantly reduced, in a dose-dependent manner, the MAP in both normotensive and hypertensive rats. Otherwise, the heart rate was not affected by any treatment. Acute and prolonged oral administration of AEAE (200mg/kg) and HCTZ caused a significant increase in volume and urinary concentrations of sodium, potassium and chloride. Moreover, urinary calcium concentration was significantly increased after administration of AEAE (200mg/kg). Finally, AEAE was able to present important in vitro antioxidant properties. CONCLUSION: The results obtained have shown that AEAE presents potent diuretic activity and significant hypotensive and antihypertensive effect. In addition, this study may confirm part of the pharmacological activity popularly attributed to this species and opens perspective for the future use in various renal and cardiovascular diseases.en_US
dc.identifier.citationAQUINO, Diana Figueiredo de Santana, et al; Alibertia edulis (L.C. Rich.) A.C. Rich - A potent diuretic arising from Brazilian indigenous species. Journal of Ethnopharmacology, v. 196, p. 193-200, 2017.en_US
dc.identifier.doi10.1016/j.jep.2016.12.024
dc.identifier.issn1872-7573
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/1435
dc.language.isoeng
dc.publisherElsevieren_US
dc.rightsopen accessen_US
dc.subject.decsBrasilen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsEcossistema Amazônicoen_US
dc.subject.decsPressão Arterialen_US
dc.subject.decsFarmacologiaen_US
dc.subject.decsPlantas Medicinaisen_US
dc.subject.decsReação Transfusionalen_US
dc.subject.otherBrasilen_US
dc.subject.otherÍndios Sul-Americanosen_US
dc.subject.otherSaúde de Populações Indígenasen_US
dc.subject.otherRegião Amazônicaen_US
dc.subject.otherMato Grosso do Sulen_US
dc.subject.otherRegião Centro Oesteen_US
dc.subject.otherPressão Arterialen_US
dc.subject.otherFarmacologiaen_US
dc.subject.otherPlantas Medicinaisen_US
dc.titleAlibertia edulis (L.C. Rich.) A.C. Rich - A potent diuretic arising from Brazilian indigenous speciesen_US
dc.typeArticleen_US
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