The microbiome of uncontacted Amerindians

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dc.contributor.authorClemente, Jose C.
dc.contributor.authorPehrsson, Erica C.
dc.contributor.authorBlaser, Martin J.
dc.contributor.authorSandhu, Kuldip
dc.contributor.authorGao, Zhan
dc.contributor.authorWang, Bin
dc.contributor.authorMagris, Magda
dc.contributor.authorHidalgo, Glida
dc.contributor.authorContreras, Monica
dc.contributor.authorNoya-Alarcón, Óscar
dc.contributor.authorLander, Orlana
dc.contributor.authorMcDonald, Jeremy
dc.contributor.authorCox, Mike
dc.contributor.authorWalter, Jens
dc.contributor.authorOh, Phaik Lyn
dc.contributor.authorRuiz, Jean F.
dc.contributor.authorRodriguez, Selena
dc.contributor.authorShen, Nan
dc.contributor.authorSong, Se Jin
dc.contributor.authorMetcalf, Jessica
dc.contributor.authorKnight, Rob
dc.contributor.authorDantas, Gautam
dc.contributor.authorDominguez-Bello, M. Gloria
dc.creator.affilliationIcahn School of Medicine at Mount Sinai. Department of Genetics and Genomic Sciences. New York, NY, USA / Icahn School of Medicine at Mount Sinai. Immunology Institute. New York, NY, USA.en_US
dc.creator.affilliationWashington University School of Medicine. Center for Genome Sciences & Systems Biology. St. Louis, MO, USA.en_US
dc.creator.affilliationVA Medical Center. Laboratory Service. New York, NY, USA / New York University School of Medicine. New York, NY, USA.en_US
dc.creator.affilliationNew York University School of Medicine. New York, NY, USA.en_US
dc.creator.affilliationNew York University School of Medicine. New York, NY, USA.en_US
dc.creator.affilliationWashington University School of Medicine. Center for Genome Sciences & Systems Biology. St. Louis, MO, USA.en_US
dc.creator.affilliationAmazonic Center for Research and Control of Tropical Diseases. Puerto Ayacucho, Venezuela.en_US
dc.creator.affilliationAmazonic Center for Research and Control of Tropical Diseases. Puerto Ayacucho, Venezuela.en_US
dc.creator.affilliationVenezuelan Institute for Scientific Research. Caracas, Venezuela.en_US
dc.creator.affilliationAmazonic Center for Research and Control of Tropical Diseases. Puerto Ayacucho, Venezuela.en_US
dc.creator.affilliationUniversidad Central de Venezuela. Instituto de Medicina Tropical. Sección de Ecología Parasitaria. Caracas, Venezuela.en_US
dc.creator.affilliationAnaerobe Systems. Morgan Hill, CA, USA.en_US
dc.creator.affilliationAnaerobe Systems. Morgan Hill, CA, USA.en_US
dc.creator.affilliationUniversity of Nebraska. Department of Food Science and Technology. Lincoln, NE, USA.en_US
dc.creator.affilliationUniversity of Nebraska. Department of Food Science and Technology. Lincoln, NE, USA.en_US
dc.creator.affilliationUniversity of Puerto Rico. Department of Biology. Rio Piedras, Puerto Rico.en_US
dc.creator.affilliationUniversity of Puerto Rico. Department of Biology. Rio Piedras, Puerto Rico.en_US
dc.creator.affilliationIcahn School of Medicine at Mount Sinai. Department of Genetics and Genomic Sciences. New York, NY, USA.en_US
dc.creator.affilliationUniversity of Colorado. Department of Chemistry and Biochemistry. Boulder, CO, USA.en_US
dc.creator.affilliationUniversity of Colorado. Department of Chemistry and Biochemistry. Boulder, CO, USA.en_US
dc.creator.affilliationUniversity of Colorado. Department of Chemistry and Biochemistry. Boulder, CO, USA / University of Colorado. Howard Hughes Medical Institute. Boulder, CO, USA.en_US
dc.creator.affilliationWashington University School of Medicine. Center for Genome Sciences & Systems Biology. St. Louis, MO, USA / Washington University School of Medicine. Department of Pathology and Immunology. St. Louis, MO, USA.en_US
dc.creator.affilliationNew York University School of Medicine. New York, NY, USA / Venezuelan Institute for Scientific Research. Caracas, Venezuela / University of Puerto Rico. Department of Biology. Rio Piedras, Puerto Rico.en_US
dc.date.accessioned2022-05-20T16:33:03Z
dc.date.available2022-05-20T16:33:03Z
dc.date.issued2015
dc.description.abstractenMost studies of the human microbiome have focused on westernized people with life-style practices that decrease microbial survival and transmission, or on traditional societies that are currently in transition to westernization. We characterize the fecal, oral, and skin bacterial microbiome and resistome of members of an isolated Yanomami Amerindian village with no documented previous contact with Western people. These Yanomami harbor a microbiome with the highest diversity of bacteria and genetic functions ever reported in a human group. Despite their isolation, presumably for >11,000 years since their ancestors arrived in South America, and no known exposure to antibiotics, they harbor bacteria that carry functional antibiotic resistance (AR) genes, including those that confer resistance to synthetic antibiotics and are syntenic with mobilization elements. These results suggest that westernization significantly affects human microbiome diversity and that functional AR genes appear to be a feature of the human microbiome even in the absence of exposure to commercial antibiotics. AR genes are likely poised for mobilization and enrichment upon exposure to pharmacological levels of antibiotics. Our findings emphasize the need for extensive characterization of the function of the microbiome and resistome in remote nonwesternized populations before globalization of modern practices affects potentially beneficial bacteria harbored in the human body.en_US
dc.identifier.citationCLEMENTE, Jose C. et al. The microbiome of uncontacted Amerindians. Science Advances, v. 1, n. 3, p. 1-12, 17 Apr. 2015.en_US
dc.identifier.doi10.1126/sciadv.1500183
dc.identifier.eissn2375-2548
dc.identifier.issn2375-2548
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/6940
dc.language.isoengen_US
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.rightsopen accessen_US
dc.subject.decsBrasilen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsEcossistema Amazônicoen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsVenezuelaen_US
dc.subject.decsFenômenos Microbiológicosen_US
dc.subject.decsMicrobiotaen_US
dc.subject.otherRegião Amazônicaen_US
dc.subject.otherYanomamien_US
dc.titleThe microbiome of uncontacted Amerindiansen_US
dc.typeArticleen_US
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