The microbiome of uncontacted Amerindians
Copyright
open access
Type
Article
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
American Association for the Advancement of Science
Alternative Title
Affilliation
Icahn School of Medicine at Mount Sinai. Department of Genetics and Genomic Sciences. New York, NY, USA / Icahn School of Medicine at Mount Sinai. Immunology Institute. New York, NY, USA.
Washington University School of Medicine. Center for Genome Sciences & Systems Biology. St. Louis, MO, USA.
VA Medical Center. Laboratory Service. New York, NY, USA / New York University School of Medicine. New York, NY, USA.
New York University School of Medicine. New York, NY, USA.
New York University School of Medicine. New York, NY, USA.
Washington University School of Medicine. Center for Genome Sciences & Systems Biology. St. Louis, MO, USA.
Amazonic Center for Research and Control of Tropical Diseases. Puerto Ayacucho, Venezuela.
Amazonic Center for Research and Control of Tropical Diseases. Puerto Ayacucho, Venezuela.
Venezuelan Institute for Scientific Research. Caracas, Venezuela.
Amazonic Center for Research and Control of Tropical Diseases. Puerto Ayacucho, Venezuela.
Universidad Central de Venezuela. Instituto de Medicina Tropical. Sección de Ecología Parasitaria. Caracas, Venezuela.
Anaerobe Systems. Morgan Hill, CA, USA.
Anaerobe Systems. Morgan Hill, CA, USA.
University of Nebraska. Department of Food Science and Technology. Lincoln, NE, USA.
University of Nebraska. Department of Food Science and Technology. Lincoln, NE, USA.
University of Puerto Rico. Department of Biology. Rio Piedras, Puerto Rico.
University of Puerto Rico. Department of Biology. Rio Piedras, Puerto Rico.
Icahn School of Medicine at Mount Sinai. Department of Genetics and Genomic Sciences. New York, NY, USA.
University of Colorado. Department of Chemistry and Biochemistry. Boulder, CO, USA.
University of Colorado. Department of Chemistry and Biochemistry. Boulder, CO, USA.
University of Colorado. Department of Chemistry and Biochemistry. Boulder, CO, USA / University of Colorado. Howard Hughes Medical Institute. Boulder, CO, USA.
Washington University School of Medicine. Center for Genome Sciences & Systems Biology. St. Louis, MO, USA / Washington University School of Medicine. Department of Pathology and Immunology. St. Louis, MO, USA.
New York University School of Medicine. New York, NY, USA / Venezuelan Institute for Scientific Research. Caracas, Venezuela / University of Puerto Rico. Department of Biology. Rio Piedras, Puerto Rico.
Washington University School of Medicine. Center for Genome Sciences & Systems Biology. St. Louis, MO, USA.
VA Medical Center. Laboratory Service. New York, NY, USA / New York University School of Medicine. New York, NY, USA.
New York University School of Medicine. New York, NY, USA.
New York University School of Medicine. New York, NY, USA.
Washington University School of Medicine. Center for Genome Sciences & Systems Biology. St. Louis, MO, USA.
Amazonic Center for Research and Control of Tropical Diseases. Puerto Ayacucho, Venezuela.
Amazonic Center for Research and Control of Tropical Diseases. Puerto Ayacucho, Venezuela.
Venezuelan Institute for Scientific Research. Caracas, Venezuela.
Amazonic Center for Research and Control of Tropical Diseases. Puerto Ayacucho, Venezuela.
Universidad Central de Venezuela. Instituto de Medicina Tropical. Sección de Ecología Parasitaria. Caracas, Venezuela.
Anaerobe Systems. Morgan Hill, CA, USA.
Anaerobe Systems. Morgan Hill, CA, USA.
University of Nebraska. Department of Food Science and Technology. Lincoln, NE, USA.
University of Nebraska. Department of Food Science and Technology. Lincoln, NE, USA.
University of Puerto Rico. Department of Biology. Rio Piedras, Puerto Rico.
University of Puerto Rico. Department of Biology. Rio Piedras, Puerto Rico.
Icahn School of Medicine at Mount Sinai. Department of Genetics and Genomic Sciences. New York, NY, USA.
University of Colorado. Department of Chemistry and Biochemistry. Boulder, CO, USA.
University of Colorado. Department of Chemistry and Biochemistry. Boulder, CO, USA.
University of Colorado. Department of Chemistry and Biochemistry. Boulder, CO, USA / University of Colorado. Howard Hughes Medical Institute. Boulder, CO, USA.
Washington University School of Medicine. Center for Genome Sciences & Systems Biology. St. Louis, MO, USA / Washington University School of Medicine. Department of Pathology and Immunology. St. Louis, MO, USA.
New York University School of Medicine. New York, NY, USA / Venezuelan Institute for Scientific Research. Caracas, Venezuela / University of Puerto Rico. Department of Biology. Rio Piedras, Puerto Rico.
Advisor
Co-Advisor
Committee Member
Organizer
Coordinator(s)
Institutional author
Director
item.page.production
Screenplay
Producer
Recorder
Abstract
Abstract
Most studies of the human microbiome have focused on westernized people with life-style practices that decrease microbial survival and transmission, or on traditional societies that are currently in transition to westernization. We characterize the fecal, oral, and skin bacterial microbiome and resistome of members of an isolated Yanomami Amerindian village with no documented previous contact with Western people. These Yanomami harbor a microbiome with the highest diversity of bacteria and genetic functions ever reported in a human group. Despite their isolation, presumably for >11,000 years since their ancestors arrived in South America, and no known exposure to antibiotics, they harbor bacteria that carry functional antibiotic resistance (AR) genes, including those that confer resistance to synthetic antibiotics and are syntenic with mobilization elements. These results suggest that westernization significantly affects human microbiome diversity and that functional AR genes appear to be a feature of the human microbiome even in the absence of exposure to commercial antibiotics. AR genes are likely poised for mobilization and enrichment upon exposure to pharmacological levels of antibiotics. Our findings emphasize the need for extensive characterization of the function of the microbiome and resistome in remote nonwesternized populations before globalization of modern practices affects potentially beneficial bacteria harbored in the human body.
Abstract in Spanish
Abstract in French
Description
Keywords in Portuguese
Região Amazônica, Yanomami
Keywords
Keywords in Spanish
Keywords in French
DeCS
Brasil, Índios Sul-Americanos, Ecossistema Amazônico, Saúde de Populações Indígenas, Venezuela, Fenômenos Microbiológicos, Microbiota
Event Date
Previous version
Related Document
Means of dissemination
Duration
Duration
Original color system
Target audience context
Audience occupation
Educational Description
Evaluation
Peer Reviewed
Publication Status
Sponsorship
Latest version
Version
Event Location
Event title
Event Type
Citation
CLEMENTE, Jose C. et al. The microbiome of uncontacted Amerindians. Science Advances, v. 1, n. 3, p. 1-12, 17 Apr. 2015.
ISBN
ISSN
2375-2548
DOI
10.1126/sciadv.1500183