Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors

Copyright
open access
Type
Article
Date
2004
Journal Title
Journal ISSN
Volume Title
Publisher
International Society on Hypertension in Blacks
Alternative Title
Affilliation
Endocrinology Section and Clinic Pathology Section of Department of Medicine, Medical Genetics Center of Morphology and Pediatrics, and Department of Preventive Medicine, Federal University of São Paulo, São Paulo. SP, Brasil.
Advisor
Co-Advisor
Committee Member
Organizer
Coordinator(s)
Institutional author
Director
item.page.production
Screenplay
Producer
Recorder
Abstract
Abstract
Hyperhomocysteinemia is a risk factor for cardiovascular disease. C677T mutation at the MTHFR gene and deficiencies of folic acid and vitamin B-12 may account for elevation of total homocysteine (tHcy). Ninety Brazilian Parkatêjê Indians (90.0% of the population without admixture, aged > or = 20 years) were studied. Hyperhomocysteinemia was observed in 26.7% of the Indians. No case of vitamin B-12 deficiency was detected. Folic acid deficiency was found in 43.3% of the subjects. Rates of mutated allele 677T and TT genotype were 40.7% and 14.0%, respectively. Prevalence of hypertension, dyslipidemia, smoking, WHR > or = 0.9, BMI > or = 25 kg/m2 and chronic alcohol use were 4.4%, 44.4%, 25.6%, 72.2%, 67.8%, and 0.0%, respectively. All creatinine values were normal. Natural logarithmic (ln) tHcy showed no correlation with age, but was positively correlated with systolic (r = 0.22) and diastolic (r = 0.21) blood pressure and triglycerides (r = 0.39) and inversely correlated with folic acid (r = -0.40) adjusted for age and sex. Total homocysteine (tHcy) was higher among TT genotype (P < 0.001). The multiple linear regression model, containing variables for sex, folic acid, TT genotype, and triglycerides, explained 50.0% of the variation of the ln tHcy. In summary, high rates of cardiovascular risk factors were discovered. C667T mutation and folic acid deficiency can explain, at least in part, the observed hyperhomocysteinemia.
Abstract in Spanish
Abstract in French
Description
Keywords in Portuguese
Brasil, Índios Sul-Americanos, Região Norte, Saúde de Populações Indígenas, Região Amazônica, Epidemiologia, Pará, Antropometria, Fatores de Risco, Pressão Arterial, Estudos Epidemiológicos, Genética Humana, Índice de Massa Corporal, Avaliação Nutricional, Dislipidemias, Parkatêjê, Deficiência de Vitaminas do Complexo B, Deficiências Nutricionais, Doenças Crônicas não Transmissíveis, Doenças Cardiovasculares, Deficiências de Micronutrientes, Deficiência de Ácido Fólico, Tabagismo
Keywords
Keywords in Spanish
Keywords in French
DeCS
Brasil, Saúde de Populações Indígenas, Índios Sul-Americanos, Ecossistema Amazônico, Epidemiologia, Antropometria, Genética Humana, Pressão Arterial, Fatores de Risco
Event Date
Previous version
Related Document
Means of dissemination
Duration
Duration
Original color system
Target audience context
Audience occupation
Educational Description
Evaluation
Peer Reviewed
Publication Status
Sponsorship
Latest version
Version
Event Location
Event title
Event Type
Citation
TAVARES, Edelweiss F.; et al. Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors. Ethnicity & Disease, v. 14, n. 1, p. 49-56, 2004.
ISBN
ISSN
1049-510X
DOI
Defense Institution
Degree date
Defense location
Programa