Genetic Clustering of Tuberculosis in an Indigenous Community of Brazil

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dc.contributor.authorCorreia Sacchi, Flávia Patussi
dc.contributor.authorTatara, Mariana Bento
dc.contributor.authorCamioli de Lima, Camila
dc.contributor.authorFerreia da Silva, Liliane
dc.contributor.authorCunha, Eunice Atsuko Totumi
dc.contributor.authorSimonsen, Vera
dc.contributor.authorFerrazoli, Lucilaine
dc.contributor.authorGomes, Harrison Magdinier
dc.contributor.authorGonçalves Vasconcellos, Sidra Ezidio
dc.contributor.authorSuffys, Philip Noel
dc.contributor.authorAndrews, Jason R.
dc.contributor.authorCroda, Julio Henrique Rosa
dc.creator.affilliationUniversidade Federal de Grande Dourados. Dourados, MS, Brasilen_US
dc.creator.affilliationUniversidade Federal de Grande Dourados. Dourados, MS, Brasilen_US
dc.creator.affilliationUniversidade Federal de Grande Dourados. Dourados, MS, Brasilen_US
dc.creator.affilliationSecretaria de Saúde Indígena. Dourados, MS, Brasilen_US
dc.creator.affilliationLaboratório Central de Saúde Pública. Campo Grande, MS, Brasilen_US
dc.creator.affilliationInstituto Adolfo Lutz. São Paulo, SP, Brasilen_US
dc.creator.affilliationInstituto Adolfo Lutz. São Paulo, SP, Brasilen_US
dc.creator.affilliationFundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasilen_US
dc.creator.affilliationFundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasilen_US
dc.creator.affilliationFundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasilen_US
dc.creator.affilliationUniversidade de Stanford. Escola de Medicina. Stanford, CA, Brasilen_US
dc.creator.affilliationFundação Oswaldo Cruz. Campo Grande, MS, Brasilen_US
dc.date.accessioned2020-02-13T12:16:52Z
dc.date.available2020-02-13T12:16:52Z
dc.date.issued2018
dc.description.abstractenWe conducted a population-based study of tuberculosis (TB) from 2009 to 2015 in an indigenous community of Brazil, the largest in the country, to investigate risk factors associated with recent TB transmission. The clinical isolates of Mycobacterium tuberculosis were genotyped by IS6110-RFLP (restriction fragment length polymorphism) and spoligotyping analysis. Among 67 isolates typed by RFLP, 69% fell into fifteen clusters, and 91% of TB cases with shared IS6110-RFLP pattern were diagnosed within 2 years of another case in the cluster. Individual risk factors associated with genetic clustering were domestic overcrowding (odds ratio [OR]: 6.10; 95% confidence interval [CI]: 1.50-24.88) and low social class (OR: 3.72; 95% CI: 1.00-13.98). Most reported contacts (76%) were identified within the household of the index TB case, but most of the genetic clustering of M. tuberculosis occurred outside of household (79%). Expanded contacts investigation and prophylaxis outside of household should be considered as a priority for TB control programs in this population.en_US
dc.identifier.citationCORREIA SACCHI, Flávia Patussi; et al. Genetic clustering of tuberculosis in an indigenous community of Brazil. Am. J. Trop. Med. Hyg, v.98, n.2, p. 372-375, 2018.en_US
dc.identifier.doi10.4269/ajtmh.17-0480
dc.identifier.issn1476-1645
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/1496
dc.language.isoeng
dc.publisherAmerican Society of Tropical Medicine and Hygieneen_US
dc.rightsopen accessen_US
dc.subject.decsBrasilen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsEpidemiologiaen_US
dc.subject.decsTuberculoseen_US
dc.subject.decsGenética Humanaen_US
dc.subject.decsInfecções Bacterianasen_US
dc.subject.otherBrasilen_US
dc.subject.otherÍndios Sul-Americanosen_US
dc.subject.otherSaúde de Populações Indígenasen_US
dc.subject.otherEpidemiologiaen_US
dc.subject.otherTuberculoseen_US
dc.subject.otherEstudos Epidemiológicosen_US
dc.subject.otherGenética Humanaen_US
dc.subject.otherDoenças Infecciosasen_US
dc.titleGenetic Clustering of Tuberculosis in an Indigenous Community of Brazilen_US
dc.typeArticleen_US
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