Genetic Clustering of Tuberculosis in an Indigenous Community of Brazil
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open access
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Article
Date
2018
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American Society of Tropical Medicine and Hygiene
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Universidade Federal de Grande Dourados. Dourados, MS, Brasil
Universidade Federal de Grande Dourados. Dourados, MS, Brasil
Universidade Federal de Grande Dourados. Dourados, MS, Brasil
Secretaria de Saúde Indígena. Dourados, MS, Brasil
Laboratório Central de Saúde Pública. Campo Grande, MS, Brasil
Instituto Adolfo Lutz. São Paulo, SP, Brasil
Instituto Adolfo Lutz. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
Universidade de Stanford. Escola de Medicina. Stanford, CA, Brasil
Fundação Oswaldo Cruz. Campo Grande, MS, Brasil
Universidade Federal de Grande Dourados. Dourados, MS, Brasil
Universidade Federal de Grande Dourados. Dourados, MS, Brasil
Secretaria de Saúde Indígena. Dourados, MS, Brasil
Laboratório Central de Saúde Pública. Campo Grande, MS, Brasil
Instituto Adolfo Lutz. São Paulo, SP, Brasil
Instituto Adolfo Lutz. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
Universidade de Stanford. Escola de Medicina. Stanford, CA, Brasil
Fundação Oswaldo Cruz. Campo Grande, MS, Brasil
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Abstract
Abstract
We conducted a population-based study of tuberculosis (TB) from 2009 to 2015 in an indigenous community of Brazil, the largest in the country, to investigate risk factors associated with recent TB transmission. The clinical isolates of Mycobacterium tuberculosis were genotyped by IS6110-RFLP (restriction fragment length polymorphism) and spoligotyping analysis. Among 67 isolates typed by RFLP, 69% fell into fifteen clusters, and 91% of TB cases with shared IS6110-RFLP pattern were diagnosed within 2 years of another case in the cluster. Individual risk factors associated with genetic clustering were domestic overcrowding (odds ratio [OR]: 6.10; 95% confidence interval [CI]: 1.50-24.88) and low social class (OR: 3.72; 95% CI: 1.00-13.98). Most reported contacts (76%) were identified within the household of the index TB case, but most of the genetic clustering of M. tuberculosis occurred outside of household (79%). Expanded contacts investigation and prophylaxis outside of household should be considered as a priority for TB control programs in this population.
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Keywords in Portuguese
Brasil, Índios Sul-Americanos, Saúde de Populações Indígenas, Epidemiologia, Tuberculose, Estudos Epidemiológicos, Genética Humana, Doenças Infecciosas
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Brasil, Saúde de Populações Indígenas, Índios Sul-Americanos, Epidemiologia, Tuberculose, Genética Humana, Infecções Bacterianas
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CORREIA SACCHI, Flávia Patussi; et al. Genetic clustering of tuberculosis in an indigenous community of Brazil. Am. J. Trop. Med. Hyg, v.98, n.2, p. 372-375, 2018.
ISBN
ISSN
1476-1645
DOI
10.4269/ajtmh.17-0480