Cytotoxic, genotoxic and mutagenic evaluation of Alibertia edulis (rich.) a. Rich. ex DC: an indigenous species from Brazil

dc.contributor.authorTolouei, Sara Emilia Lima
dc.contributor.authorTraesel, Giseli Karenina
dc.contributor.authorFreitas de Lima, Fernando
dc.contributor.authorSouza de Araújo, Flávio Henrique
dc.contributor.authorHonaiser Lescano, Caroline
dc.contributor.authorCardoso, Claudia Andrea Lima
dc.contributor.authorOesterreich, Silvia Aparecida
dc.contributor.authorVieira, Maria do Carmo
dc.date.accessioned2022-01-17T19:39:04Z
dc.date.available2022-01-17T19:39:04Z
dc.date.issued2018
dc.description.abstractenTea leaves of Alibertia edulis is popularly used in folk medicine. However, studies on the genotoxicity of this plant are not available. We aimed to investigate the in vivo and in vitro cytotoxic, genotoxic and mutagenic potentials of the aqueous extract of A. edulis leaves (AEAE). Antioxidant assays, the Artemia salina test, MTT in human platelets, micronucleus in bone marrow and comet in peripheral blood were performed. Animals received four different doses of the AEAE by oral gavage for 30 days. Saline and cyclophosphamide were used as controls. The AEAE exhibited a maximal inhibition at 100 and 250 µg/mL, according to the ABTS and DPPH methods, respectively. The A. salina assay showed that the AEAE presented some toxicity at doses of 100, 250 and 500 μg/mL. Through the MTT assay, the AEAE showed no toxic effects on human platelets during the incubation period. The alkaline comet assay showed that all doses of the AEAE were statistically similar to the negative control group since they did not induce any significant increase of the overall number of damaged cells nor the severity of the cell damage. In the micronucleous assay, results demonstrate that the AEAE did not increase the production of micronucleated polychromatic erythrocytes and was statistically similar to the negative control. The four doses of the plant extract did not affect the production of new erythrocytes and were statistically similar to the negative control groups. Furthermore, the AEAE demonstrated no cytotoxicity, genotoxicity and mutagenicity at the doses tested in ratsen_US
dc.identifier10.1080/01480545.2018.1488862
dc.identifier1525-6014
dc.identifier.citationTOLOUEI, Sara Emilia Lima; et al. Cytotoxic, genotoxic and mutagenic evaluation of Alibertia edulis (rich.) a. Rich. ex DC: an indigenous species from Brazil. Drug and Chemical Toxicology, v. 43, n. 2 , p. 200-207, 2018en_US
dc.identifier.issn10.1080/01480545.2018.1488862
dc.identifier.issn1525-6014
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/5864
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsopen accessen_US
dc.subject.decsBrasilen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsMedicina Tradicionalen_US
dc.subject.decsPlantas Medicinaisen_US
dc.subject.decsTestes de Toxicidadeen_US
dc.subject.decsCiclofosfamidaen_US
dc.subject.enArtemia Salinaen_US
dc.subject.enMicronuleien_US
dc.subject.enCometen_US
dc.subject.enGenotoxicityen_US
dc.subject.enCyclophosphamideen_US
dc.subject.otherRegião Centro-Oesteen_US
dc.subject.otherMato Grosso do Sulen_US
dc.subject.otherDoenças e Agravos Não Transmissíveisen_US
dc.titleCytotoxic, genotoxic and mutagenic evaluation of Alibertia edulis (rich.) a. Rich. ex DC: an indigenous species from Brazilen_US
dc.typeArticleen_US
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