Haplotype and allele frequencies for three genes of the dopaminergic system in South American Indians

dc.contributor.authorHutz, Mara H.
dc.contributor.authorAlmeida, Silvana de
dc.contributor.authorCoimbra Junior, Carlos Everaldo Alvares
dc.contributor.authorSantos, Ricardo Ventura
dc.contributor.authorSalzano, Francisco M.
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasilen_US
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasilen_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Departamento de Endemias. Rio de Janeiro, RJ, Brasil.en_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Departamento de Endemias. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Museu Nacional, Departamento de Antropologia. Rio de Janeiro, RJ, Brasilen_US
dc.date.accessioned2019-10-03T17:59:12Z
dc.date.available2019-10-03T17:59:12Z
dc.date.issued2000
dc.description.abstractenHaplotype and allele frequencies for the dopamine D2 receptor gene (DRD2), dopamine D4 receptor gene (DRD4), and dopamine transporter protein gene (SLC6A3) were determined in 135 individuals from five Brazilian Indian tribes, and the results integrated with those previously presented for this ethnic group. DRD2 and DRD4 were highly polymorphic. Haplotypes including TaqI A1 at DRD2, and the seven repeat allele at DRD4 were the most frequent variants, while the SLC6A3 locus was monomorphic for the 10 repeat allele in South American Indians. Genetic distances and the corresponding neighbor-joining tree indicated a geographic dichotomy between North + Central American and South American natives, with the exception of the Wai Wai, who live north of the Amazon river and are grouped in the northern cluster. G(ST) estimates from these genes vary between 0.05 and 0.11 for North and South America, respectively, indicating a higher degree of differentiation of the latter groups. These results are in accordance with previous genetic data on other systems, as well as with the history and biodemographical data of South American Indians.en_US
dc.identifier10.1002/1520-6300(200009/10)12:5<638
dc.identifier1520-6300
dc.identifier.citationHUTZ, Mara H. et al. Haplotype and allele frequencies for three genes of the dopaminergic system in South American Indians. American Journal of Human Biology, v. 12, n. 5, p. 638-645, 2000.en_US
dc.identifier.doi10.1002/1520-6300(200009/10)12:5<638
dc.identifier.issn1520-6300
dc.identifier.urihttps://repositorio.bvspovosindigenas.fiocruz.br/handle/bvs/1143
dc.language.isoeng
dc.publisherWiley-Lissen_US
dc.rightsopen accessen_US
dc.subject.decsBrasilen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsEcossistema Amazônicoen_US
dc.subject.decsGenética Humanaen_US
dc.subject.otherBrasilen_US
dc.subject.otherÍndios Sul-Americanosen_US
dc.subject.otherRegião Norteen_US
dc.subject.otherSaúde de Populações Indígenasen_US
dc.subject.otherMato Grossoen_US
dc.subject.otherRegião Amazônicaen_US
dc.subject.otherParáen_US
dc.subject.otherRegião Centro-Oesteen_US
dc.subject.otherGaviãoen_US
dc.subject.otherSuruíen_US
dc.subject.otherRondôniaen_US
dc.subject.otherXavanteen_US
dc.subject.otherZoróen_US
dc.subject.otherWai Waien_US
dc.subject.otherGenética Humanaen_US
dc.titleHaplotype and allele frequencies for three genes of the dopaminergic system in South American Indiansen_US
dc.typeArticleen_US
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